Paxillin is a recently identified member of the complex of cytoskeletal proteins that is found concentrated in cultured cells and in vivo at the cytoplasmic face of regions of cell attachment to the extracellular matrix. These sites, in view of their close proximity to the extracellular matrix, are well positioned to act as signal‐transducing centers to ‘report on’ changes in the cells, immediate environment. Recent findings indicate that such signals are in part mediated through the activation of tyrosine kinases concentrated (...) at the sites of adhesion. Changes in the phosphotyrosine content of paxillin accompanying this elevation in kinase activity suggest that paxillin may be an important intermediary in these pathways. (shrink)

John Stuart Mill's defense of freedom of discussion in On Liberty remains a major influence on philosophical and public debates about free speech. By highlighting underappreciated textual evidence and key distinctions, this introduction attempts to show how the contributions of the symposium authors – Melina Constantine Bell, Rafael Cejudo, Christopher Macleod, and Dale E. Miller – point toward a more complete account of Mill's views.

This groundbreaking handbook of character strengths and virtues is the first progress report from a prestigious group of researchers who have undertaken the systematic classification and measurement of widely valued positive traits. Character Strengths and Virtues classifies twenty-four specific strengths under six broad virtues that consistently emerge across history and culture. This book demands the attention of anyone interested in psychology and what it can teach about the good life.

It is frequently contended that one of the gravest dangers of the future of civilization is that the organization of society will be carried so far as to imperil, if not indeed to destroy, social and individual liberty. If this is actually true, we seem compelled to choose between these two ends—either, that is to say, to subordinate or sacrifice freedom, or to minimize organization.

Not in the lay mind only, but also to a wide extent throughout the realm of Science itself, there exists the belief that no matter how thoroughly research is pursued, it can never yield anything more than descriptions of whatever it may be concerned with. Undeniably, such descriptions are becoming so complicated in detail, and at the same moment so far-ranging in their applications, that they inevitably assume the aspect of more or less final explanations; and previous investigators often regarded (...) them as being actually explanatory, finding indeed in this supposed result one of the most powerful impulses to carry their inquiries to their utmost limit. This however, it is frequently contended, is at best a short-sighted error and at worst a misleading superstition; the truth, no matter how unwelcome it may seem, being that explanation is unattainable because it is a wholly non-scientific category and ideal. If then we wish to discover any sufficient reason, any ultimate ground, any final solution, we must turn from Science to Philosophy; and even so, many sceptics do not hesitate to add, we are foredoomed to disappointment. (shrink)

The problem of the nature and scope of Causation has again been raised into prominence by recent research on atomic structures and processes, the result being that many physicists maintain that the causational principle must now be restricted to macroscopic changes regarded as the averaged outcome of microscopic events, each of which alone may not be causally determined, or at least not completely so. Of this markedly new departure Professor Eddington is perhaps the best-known advocate. “Physics,” he asserts, “is no (...) longer pledged to a scheme of deterministic law; the search for a scheme of strictly causal law not practical politics.” But the issue concerns not Physics only, for Dr. Eddington at once proceeds to interpret his viewpoint by contending that “science withdraws its opposition to free will”; and thus the realms of consciousness and conduct are once more brought into intimate connection with the realm of physical phenomena. It must of course be recognized that the question still remains highly debatable; for, as Sir Oliver Lodge has recently urged, “break down causality, and we are left with chance. That is wholly unsatisfactory. Chance is no solution”; and he likewise expands his survey beyond Physics by adding, “not in that way would I aim at freedom.” It is scarcely necessary to refer to current controversy in the biological sphere, between those who regard living processes as falling, if only to some degree, outside the domain of causal action, and those who insist that such action is universal, the indubitable proof of their position being prevented only by the difficulties of investigation. (shrink)

Few current problems have become so confused as that of Value. Its increasing importance in all departments of modern thought has made it the focal point of so many diverse aspects that the result seems a mass of formidable contradictions. But these can never be overcome by attempting to simplify the situation, which must on the contrary be recognized from the outset as presenting an extreme complexity that will inevitably advance pan passu with the advancing complexities of human experience. If, (...) then, simplification is impossible, the only alternative is to attempt to grasp the salient features and present these in their true relation, in the same way that an invading army seizes the principal bases of hostile territory. (shrink)

Advertising and other forms of promotional activity have proliferated to such an extent that they may constitute a form of social pollution (Kitchen, 1994). The quantity and tone of communications to which consumers are exposed may have a subtle but pervasive effect on the social ecology of the developed world. Not only are Marketing Communications delivered in unprecedented quantities (Kitchen, 1994); but their tone is increasingly difficult to categorise in the Postmodern Marketing era (Brown, 1994). Notably, there has been very (...) little research conducted on this seeming "Leviathan" (Kitchen, 1994, after Hobbes, 1651) effect. Ethical concerns of professional marketing bodies such as the MRS and CIM are focussed on the conduct of professionals with regard to law and notions of moral decency in human exchange relationships (see MRS code of conduct, ASA and IBA guidelines). There is less emphasis on the ethical implications for society of the totality of Marketing Communication activities. This paper examines the distinctively Postmodern concept of the Communications Leviathan and discusses contemporary ethical issues, drawing perspectives where possible from Postmodern critical theory, Enlightenment philosophy, cognitive psychology and classical ethical works of Plato and Aristotle. (shrink)